Early-phase rotator training impairs tissue repair and functional recovery after spinal cord injury

Spinal cord injury (SCI) is a devastating disorder that often results in severe sensorimotor function impairment with limited recovery of function. In recent years, rehabilitation training for spinal has gradually emerged, and some them play an important role the repair However, optimal regimen SCI remains to be determined. this study, we explore effects rotarod (began at 7 days post-injury) on motor after SCI, as well its possible mechanism from aspects histopathological changes, behaviors specific trophic factors cytokines, expression profile genes. Multiple functional assessments showed initiated post-injury unsuitable promoting neuro-electrophysiological improvement trunk stability, but impaired coordination recovery. addition, negative which manifested increase lesion area, decrease neuronal viability, deterioration immuno-microenvironment remyelination, significant reduction pro-inflammatory factors. RNA sequencing suggested genes associated angiogenesis synaptogenesis were significantly downregulated PI3K-AKT pathway was inhibited, detrimental impeded nerve regeneration. These indicate immediate currently mice.